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Pinch a small fold of skin between the thumb and index finger

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The Stanford PNAS study noted striking sex-specific differences in this regard, finding that male ME/CFS and Long COVID patients exhibited pronounced mitochondrial lipid oxidative damage mediated by a failure in Glutathione Peroxidase 4 pathways

If fasting glucose is trending upward, if IGF-1 exceeds normal ranges, or if side effects are becoming unmanageable, this is the point to reassess the protocol